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FATUMO'S LAB


The Team

Principal Investigator

Associate Professor Segun Fatumo

email (Uganda)| email (London)|

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Dr. Segun Fatumo is a computational geneticist, Associate Professor of Genetic Epidemiology and Bioinformatics at the London School of Hygiene and Tropical Medicine (LSHTM), Fellow of the Advance HE, and a Wellcome International Fellow. He leads The African Computational Genomics (TACG) Research group at the MRC/UVRI and LSHTM. His group’s expertise includes but not limited to GWAS, meta-analysis, Multi-variates GWAS, Genetic Risk Score, Fine Mapping, Mendelian randomisation studies and Drug Discovery. He was recently (July 2020) awarded the prestigious Wellcome International Intermediate Fellowship to lead an innovative research programme at the MRC/UVRI and LSHTM.

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Staff Scientists/PostDoc Fellows

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Dr. Abram Kamiza

Abram Kamiza completed his PhD and MSc in Genetic Epidemiology at the School of Public Health, Taipei Medical University in Taiwan in 2018 and 2015, respectively and a bachelor’s degree in Medical Laboratory Science and Technology in 2010 at the University of Malawi, College of Medicine. His PhD thesis focused on identifying genetic and environmental factors associated with colorectal cancer in patients with Lynch syndrome in Taiwan. His research interest is to identify environmental, genetic, and epigenetic factors associated with the development of cancer and cardiovascular diseases. Abram has been working on the ERICA-SA project to identify genetic risk factors associated with cancer development in the black South African population using a genome-wide approach. He is also collaborating with other researchers to evolve the risk factors for cardiovascular diseases in individuals of African ancestry.


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Dr. Opeyemi Soremekun

opeyemisoremekun@gmail.com

Opeyemi obtained his BSc. in Biochemistry from Madonna University, Nigeria, and his M.Sc. in Biochemistry (Cancer Research and Molecular Biology) from University of Ibadan, Nigeria. He got his PhD in Computational Biology (Drug Design and Development) from University of KwaZulu-Natal, South Africa. Opeyemi has experience in the use of Bioinformatics and statistical methods in the analysis of genomic data. Presently, his research involves the use of Mendelian randomisation approaches to assess the causal relationships between cardio metabolic traits/diseases and kidney functions in African populations. Some of his publications can be accessed here.


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Dr. Allan Kalungi

Dr. Allan Kalungi obtained his BSc in Biochemistry and MSc in Molecular Biology & Biotechnology in 2007 and 2014 respectively from Makerere University, Uganda and a PhD in Psychiatry in 2020 from Stellenbosch University, South Africa. He pioneered neuropsychiatric genetics research in East Africa in 2014 when he produced the first neuropsychiatric genetics article from the region which reported the association between serotonin transporter gene polymorphisms and increased suicidal risk among adult Ugandans living with HIV. His PhD study investigated the role of telomere length and selected genetic variants in influencing the risk for internalizing mental disorders (depression, anxiety and post-traumatic stress disorder) among Ugandan HIV+ children and adolescents and he published a number of articles out of this study. In 2017, he was also an inaugural fellow in the Global Initiative for Neuropsychiatric Genetics Education in Research (GINGER; https://ginger.sph.harvard.edu/) program at the Harvard T.H. Chan School of Public Health and the Broad Institute, a programme which aims to prepare a new generation of neuropsychiatric genetics researchers in Africa, and he successfully completed it in 2020.He is also interested in studying whether the comorbidity between major depressive disorder and schizophrenia is genetically distinct from depression and he hopes to use NeuroGAP data as well as data from the schizophrenia group of the Psychiatric Genomics Consortium (PGC) and the major depressive disorder group of the PGC respectively to investigate this.




PhD Students

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Christopher Kintu

christopherkintu@gmail.com

I am currently pursuing a PhD in Bioinformatics at Makerere University, Kampala Uganda under the supervision of Prof Segun Fatumo. I hold a masters degree in Immunology and Clinical Microbiology and a Bachelors degree in Biochemistry, both from Makerere University, Uganda.

My PhD thesis is focusing on developing the first Polygenic Risk Scores (PRS) for prediction of Chronic Kidney Diseases (CKD) within African populations. We will evaluate best approaches for using a diverse discovery dataset from trans-ethnic Genome-wide association studies (GWAS) meta-analysis and a target dataset individuals from continental Africa to develop and evaluate a novel PRS for prediction of CKD.


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Mayanja Richard

mayanjarichard39@gmail.com

I am Mayanja Richard, a PhD student in Bioinformatics from Makerere University, Uganda under the supervision of Prof Segun Fatumo.

My PhD work centres around an assessment the aetiological insights into Chronic kidney disease (CKD) including integration of genomic data to perform large-scale GWAS of estimated glomerular filtration rate (eGFR), a measure of kidney function that defines CKD in ~26K individuals from continental Africa, thus providing unique opportunities for the discovery of new disease susceptibility loci.


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Chisom Ezenwa

chisomezenwa2014@gmail.com

Chisom Ezenwa Soremekun is a Research Associate at the Center for Genomics Research and Innovation, National Biotechnology Development Agency (CGRI-NABDA), Abuja, Nigeria. She is also a PhD student at Makerere University, Uganda where she will be working on the GWAS of type-2 diabetes in Africa. Chisom holds a Bachelors and Master's degree in Biochemistry from the University of Ibadan, Nigeria. She has attended several Bioinformatics training which includes; Introduction to Bioinformatics Training (IBT) and Intermediate Bioinformatics Training (Int_BT) both organized by H3ABioNet. She has also served as Teaching Assistants for the IBT course. In 2020, Chisom was awarded the H3ABioNet Training Fellowship to acquire applied bioinformatics skills at the Sydney Brenner Institute for Molecular Bioscience (SBIMB),University of Witwatersrand, Johannesburg, South Africa. Presently, she is working on the Multivariate Genome Wide Association Study analysis of the Liver Function Traits (LFTs) in the African population. Chisom enjoys traveling and reading.


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Sarah Silva

Sarah is currently pursuing a PhD in Epidemiology and Public Health at the London School of Hygiene and Tropical Medicine under the primary supervision of Prof Dr. Segun Fatumo. She holds a master's degree in Genomic Medicine from Barts and The London School of Medicine and Dentistry (QMUL) and a bachelor's degree in Genetics from the University of Liverpool. Her current research pertains to studying the genetics of risk factors associated with Coronary Heart Disease (CHD) and how they differ between ethnicities. Through the development of unique polygenic risk scores and disentangling contextual influence on CHD penetrance for each ethnicity under investigation, the efficacy of stratified and precision medicine through means of the adoption and implementation of ethnicity data will be assessed.


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Brenda Udosen

brendaumoh6@gmail.com

I obtained my BSc in the field of Genetics and Biotechnology from the university of Calabar, Calabar, Nigeria. At the completion of my degree, I did a one-year internship program at the National Biotechnology Development Agency, in the department of canter for genomic research innovation Abuja, Nigeria. After which I undertook MSc in Bioinformatics in Africa Centre of excellence in Bioinformatics, Bamako, Mali. My thesis research project was focused on identifying genetic variants associated with blood pressure traits using Genome wide association analyses approach in individuals from African descent.


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Abdoulaye Diawara

Abdoulaye Diawara is a PhD student at African Centre of Excellence in Bioinformatics, University of Sciences, Techniques and Technologies of Bamako (USTTB). His research is focused on using bioinformatics and genomics tools to find genetic variations contributing to susceptibility of certain human disease such as diabetes and malaria (drug resistance).




Masters Students

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Mariam Traoré

Mariam Traoré is currently a master student in Bioinformatics at the African Center for Excellence in Bioinformatics (ACE-B) at University of Sciences of Techniques and Technologies of Bamako (USTTB). She obtained a doctoral degree in Pharmacy from the Faculty of Pharmacy of the University of Sciences of Techniques and Technologies of Bamako (USTTB) in 2019. After her graduation, she joined the Laboratory of Applied Molecular Biology (LBMA) at the same university as a junior researcher. She worked on a project focused on conducting surveillance of malaria drug resistance in Mali with funding from the US President Malaria Initiative program (PMI). From 2020 to 2021, she was actively involved in the COVID-19 response team, specifically molecular diagnosis of suspected cases, at the same laboratory. Her master project focuses on investigating the causal effect of malaria infection on metabolic diseases in African Ancestry Individuals using Mendelian Randomization.


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Irene Namara

Irene Namara, A graduate student pursuing a Master's degree in Bioinformatics at the African Centre of Excellence in Bioinformatics at Makerere University in Uganda. Currently a research intern at The African Computational Genomics at MRC/UVRI&LSHTM. My research project is on the Sero-epidemiology of SARS-CoV-2 in the Entebbe Mother and Baby Study (EMaBS) birth cohort. I hold a Bachelor's degree in Biomedical Laboratory Technology from Makerere University, Uganda. I have a professional goal of continuous career development towards becoming a resource in applying Bioinformatics knowledge to improve biomedical research. I am resourceful with common Bioinformatics skills and skilled at project support with a history of solution oriented problem solving. I am hardworking, self -driven and passionate about Bioinformatics and would like to become part of a team that works towards using Bioinformatics approaches to solve health related challenges.



Associate Member


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Oudou Diabaté

diabateoudou@gmail.com

Mr. Oudou Diabaté, Master ofBioinformatics at the African Center of Excellence in Bioinformatics (ACE-B), Mali 2020. After obtaining his teaching diploma , 2011; he taught for five years at the fundamental school of Segala (Kayes-Mali) specializing in Natural Sciences-Physical-Chemistry. Considering his ambitions for science, he attended the Faculty of Technical and Technological Sciences of Bamako, option CBG (Chemistry-Biology-Geology) where he obtained a bachelor degree in Biochemistry-Microbiology, 2018. With this degree, he did four-month internship at the Reference Health Center of the sixth commune of Bamako in the medical analysis laboratory. This last internship allowed him to see an even wider field of science.

During his master training in bioinformatics, he did an internship at the MRTC (Malaria Research and Training Center) with Laurent DEMBELE, Ing, Msc, PhD, working on manipulations for the testing of drug candidates against antimalarial resistance. His master thesis was “In silico analysis of Pfdhfr gene mutations and their effects on the protein function in Mali” supervised by Pr. Ousmane KOITA et Dr. Cheickna CISSE. This project was funded by the West African Center of Excellence in Bioinformatics (WACE- B). Now, he’s working on a SEED GRANT project, founding by WACE-B. In this project, he is looking for new drug to fight against the SARS-CoV-2 main protease. This project is supervising by Pr. Mamadou WELE and Dr. Cheickna CISSE.



Alumni

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Mariam Nakabuye

mnakabuye@gmail.com

Current Position: Graduate Intern at University of Copenhagen




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Sounkou Mahamane, Toure

toure@computationalgenomics.org |sounkoutoure@gmail.com | stoure@tulane.edu

Current Position: Bioinformatician




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Hanan Musa

Current Position: Doctoral Candidate at University of Oslo






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Ritah Nabunje

Current Position: Doctoral Candidate at University of Leicester